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BLZ-100 is the first Tumor Paint product candidate that is being developed for cancer surgery in multiple solid tumor types. BLZ-100 is a drug administered by IV injection that circulates within the body and “light ups” cancer cells.

Safety Study of BLZ-100 in Adult Subjects With Glioma Undergoing Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Blaze began an open-label, U.S. Phase I trial to evaluate IV BLZ-100 in up to 30 adult patients undergoing surgical resection of their solid tumors.

BLZ-100 is the first product candidate from Blaze’s Tumor Paint platform and consists of an Optide (optimized peptide), which binds and internalizes into cancer cells, and a fluorescent dye ...

BLZ-100 (tozuleristide) was found to be well-tolerated by patients and to make breast cancer tumors more easily seen during surgery in a Phase 1 clinical trial, Blaze Bioscience announced. BLZ-100 was used to “paint” tumors to better guide surgeons while operating.

Change in concentration of BLZ-100 in the blood [ Time Frame: Prior to dosing and at 10 minutes, 30 minutes, and 60 minutes post BLZ-100 administration ] BLZ-100 levels in blood will be analyzed by chemical means and these data will be used to calculate pharmacokinetic parameters.

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In conjunction with BLZ-100, we are nearing completion of developing and optimizing an imaging system (SIRIS) for in-vivo imaging of BLZ-100 for use in surgical resections of gliomas. Methods: BLZ-100 concentrations were prepared in a 5% intralipid solution.

Surgeons may be able to see—and remove—skin cancers completely, thanks to a new compound that tags tumors. Called BLZ-100, the experimental compound combines a fluorescent dye with a protein fragment that binds cancer cells.

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Blaze Bioscience, Inc. is a privately held biotechnology company focused on guided therapies. Blaze was founded in 2010 by Dr. Jim Olson, a pediatric neuro-oncologist at the Fred Hutchinson Cancer Research Center and Seattle Children’s Hospital, and Heather Franklin, a former senior business executive from ZymoGenetics. ... BLZ-100, is in ...